Journal: PLoS ONE
Article Title: A Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST
doi: 10.1371/journal.pone.0156223
Figure Lengend Snippet: Steady-state distributions of output states were generated from the final PBN model using the optPBN toolbox. The mean and standard deviation (SD) of steady-state distribution from ten rounds of simulation (black stars [mean] and error bars [SD] on top) were compared against the experimental data from the training dataset (multi-coloured squares [mean] and error bars [SD] on bottom). Six experimental conditions as labelled on the x-axis are in the following order: DV-WT (WT[-]), DV-WT-Wortmannin (WT[W]), DV-WT-U0126 (WT[U]), DV-dMAPK (dM[-]), DV-dPI3K (dP[-]), and negative control (no doxycycline induction, ND).
Article Snippet: This implementation is integrated in the latest version of the optPBN toolbox (version 2.2.3) available on http://sourceforge.net/projects/optpbn .
Techniques: Generated, Standard Deviation, Negative Control